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Identification of ATP2B4 Regulatory Element Containing Functional Genetic Variants Associated with Severe Malaria

Archive ouverte | Nisar, Samia | CCSD

International audience. Genome-wide association studies for severe malaria (SM) have identified 30 genetic variants mostly located in non-coding regions. Here, we aimed to identify potential causal genetic variants ...

Unraveling a novel dual-function regulatory element showing epistatic interaction with a variant that escapes genome-wide association studies

Archive ouverte | Adjemout, Mathieu | CCSD

Regulation of gene expression has recently been complexified by the identification of Epromoters, a subset of promoters with enhancer function. Here, we uncovered the first dual cis-regulatory element, "ESpromoter," exhibiting bot...

NCR3 polymorphism, haematological parameters, and severe malaria in Senegalese patients

Archive ouverte | Thiam, Alassane | CCSD

International audience. Background. Host factors, including host genetic variation, have been shown to influence the outcome of Plasmodium falciparum infection. Genome-wide linkage studies have mapped mild malaria r...

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