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Molecular mechanisms of TAD boundary formation

Archive ouverte | Valton, Anne-Laure | CCSD

International audience. Over the last decade, it is increasingly appreciated that the 3D organization of the genome in the cell nucleus contributes to gene regulation, genome stability and chromosome inheritance. Du...

identification of cis-DNA sequences necessary for replication initiation in vertebrates. Identification de séquences cis-nucléiques nécessaires à l'initiation de la réplication chez les vertébrés

Archive ouverte | Valton, Anne-Laure | CCSD

Most origins of replication mapped in mouse and human cells are associated with a G-rich motif that can form a G-quadruplex (G4). However, experimental proofs showing whether G4 are necessary for replication initiation in vertebra...

Compartment variegation in mammalian cell culture

Archive ouverte | Valton, Anne-Laure | CCSD

International audience. In the interphase nucleus, the folding of the DNA varies at different genomic scales. At the mega base level chromatin folds into transcriptionally active A compartments and transcriptionally...

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