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Doublecortin Is a Developmentally Regulated, Microtubule-Associated Protein Expressed in Migrating and Differentiating Neurons

Archive ouverte | Francis, Fiona | CCSD

International audience

The RhoGAP activity of OPHN1, a new F-actin-binding protein, is negatively controlled by its amino-terminal domain

Archive ouverte | Fauchereau, Fabien | CCSD

Recent human genetic approaches showed that mutations in three genes encoding OPHN1, PAK3, and alphaPIX cause nonspecific X-linked mental retardation. These three proteins act to modulate Rho GTPase signaling pathways and may part...

Doublecortin interacts with the ubiquitin protease DFFRX, which associates with microtubules in neuronal processes

Archive ouverte | Friocourt, Gaëlle | CCSD

International audience. Doublecortin (DCX) is a microtubule-associated protein involved in neuronal migration, which causes X-linked lissencephaly and subcortical laminar heterotopia (SCLH) when mutated. Here we sho...

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