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Structure-activity relationships of methylene or terminal side chain modified retinoids on the differentiation and cell death signaling in NB4 promyelocytic leukemia cells

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Ivanova, Diana | Rossin, Aurélie | Gronemeyer, Hinrich | Valla, Alain | Cartier, Dominique | Le Guillou, Régis | Labia, Roger

Edité par CCSD ; Elsevier -

New structure-activity relationships of a series of methylene or side chain modified retinoids on NB4 acute promyelocytic leukemia cells are investigated. The differentiation- and apoptosis-inducing potential of these compounds is analyzed on the basis of their selective retinoic acid receptor binding profile.

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