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Transcription activities at 8-oxoG lesions in DNA

Archive ouverte | Larsen, Elisabeth | CCSD

7,8-Dihydro-8-oxoguanine (8-oxoG) is the most frequent mutagenic lesion caused by oxidative stress. Eukaryotic cells use a specific DNA glycosylase, OGG1, to excise 8-oxoG from DNA. The mild phenotype of OGG1 null mice has been at...

DNA Damage Recognition by XPA Protein Promotes Efficient Recruitment of Transcription Factor II H

Archive ouverte | Nocentini, Silvano | CCSD

International audience. The human basal transcription factor IIH (TFIIH) is an essential component of the nucleotide excision repair machinery. TFIIH is required for reaction steps concomitant with or prior to the f...

The Long Road to Understanding RNAPII Transcription Initiation and Related Syndromes

Archive ouverte | Coin, Frédéric | CCSD

International audience. In eukaryotes, transcription of protein-coding genes requires the assembly at core promoters of a large preinitiation machinery containing RNA polymerase II (RNAPII) and general transcription...

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