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Temporally controlled targeted somatic mutagenesis in skeletal muscles of the mouse.

Archive ouverte | Schuler, Michael | CCSD

International audience. To generate temporally controlled targeted somatic mutations selectively and efficiently in skeletal muscles, we established a transgenic HSA-Cre-ER(T2) mouse line in which the expression of ...

PGC1alpha expression is controlled in skeletal muscles by PPARbeta, whose ablation results in fiber-type switching, obesity, and type 2 diabetes.

Archive ouverte | Schuler, Michael | CCSD

International audience. Mice in which peroxisome proliferator-activated receptor beta (PPARbeta) is selectively ablated in skeletal muscle myocytes were generated to elucidate the role played by PPARbeta signaling i...

Temporally controlled site-specific mutagenesis in the germ cell lineage of the mouse testis

Archive ouverte | Weber, Philipp | CCSD

We have obtained a PrP-Cre-ER(T) transgenic mouse line (28.8) that selectively expresses in testis the tamoxifen-inducible Cre-ER(T) recombinase under the control of a mouse Prion protein (PrP) promoter-containing genomic fragment...

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