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Functional role of RXRs and PPARgamma in mature adipocytes.

Archive ouverte | Metzger, Daniel | CCSD

The peroxisome proliferator-activated receptor gamma (PPARgamma) is abundantly expressed in adipocytes, and plays an important role in adipocyte differentiation and fat accretion. It is a heterodimeric partner of the retinoid X re...

Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity

Archive ouverte | Imai, Takeshi | CCSD

Retinoid X receptors (RXRs) are involved in a number of signaling pathways as heterodimeric partners of numerous nuclear receptors. Hepatocytes express high levels of the RXRalpha isotype, as well as several of its putative hetero...

Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse

Archive ouverte | Imai, Takeshi | CCSD

The peroxisome proliferator-activated receptor gamma (PPARgamma) mediates the activity of the insulin-sensitizing thiazolidinediones and plays an important role in adipocyte differentiation and fat accretion. The analysis of PPARg...

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