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Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors

Archive ouverte | Ghozland, Sandy | CCSD

Repeated THC administration produces motivational and somatic adaptive changes leading to dependence in rodents. To investigate the molecular basis for cannabinoid dependence and its possible relationship with the endogenous opioi...

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Archive ouverte | Matthes, Hans | CCSD

International audience

A novel anxiogenic role for the delta opioid receptor expressed in GABAergic forebrain neurons

Archive ouverte | Chu Sin Chung, Paul | CCSD

International audience. BACKGROUND: The delta opioid receptor (DOR) is broadly expressed throughout the nervous system; it regulates chronic pain, emotional responses, motivation, and memory. Neural circuits underly...

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