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Bifunctional Therapeutic Peptides for Targeting Malignant B Cells and Hepatocytes: Proof of Concept in Chronic Lymphocytic Leukemia

Archive ouverte | Simon-Gracia, Lorena | CCSD

International audience. Protein-protein interactions are well recognized as therapeutic targets and therefore interfering peptides (IP) that block these interactions are receiving increasing attention. Four differen...

Bi-Functional Peptides as a New Therapeutic Tool for Hepatocellular Carcinoma

Archive ouverte | Savier, Eric | CCSD

International audience. Background: The interfering peptides that block protein–protein interactions have been receiving increasing attention as potential therapeutic tools. Methods: We measured the internalization ...

Preclinical Validation of Tumor-Penetrating and Interfering Peptides against Chronic Lymphocytic Leukemia

Archive ouverte | Simón-Gracia, Lorena | CCSD

International audience. Chronic lymphocytic leukemia (CLL) is the most common form of leukemia in adults. The disease is characterized by the accumulation of tumoral B cells resulting from a defect of apoptosis. We ...

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