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EZH2 mutations in follicular lymphoma distort H3K27me3 profiles and alter transcriptional responses to PRC2 inhibition

Archive ouverte | Romero, Pierre | CCSD

International audience. Mutations in chromatin regulators are widespread in cancer. Among them, the histone H3 lysine 27 methyltransferase Polycomb Repressive Complex 2 (PRC2) shows distinct alterations according to...

Drugging histone methyltransferases in cancer

Archive ouverte | Richart, Laia | CCSD

International audience. Targeting chromatin-modifying enzymes is a promising strategy for cancer treatment. The antitumor effectivity of compounds inhibiting histone methyltransferases - mainly EZH2 - is currently b...

XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation

Archive ouverte | Richart, Laia | CCSD

International audience. X inactivation (XCI) is triggered by upregulation of XIST, which coats the chromosome in cis, promoting formation of a heterochromatic domain (Xi). XIST role beyond initiation of XCI is only ...

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