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EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

Archive ouverte | Ragazzini, Roberta | CCSD

International audience. The Polycomb group of proteins is required for the proper orchestration of gene expression due to its role in maintaining transcriptional silencing. It is composed of several chromatin modify...

Impaired PRC2 activity promotes transcriptional instability and favors breast tumorigenesis

Archive ouverte | Wassef, Michel | CCSD

International audience. Alterations of chromatin modifiers are frequent in cancer, but their functional consequences often remain unclear. Focusing on the Polycomb protein EZH2 that deposits the H3K27me3 (trimethyla...

EZH2 mutations in follicular lymphoma distort H3K27me3 profiles and alter transcriptional responses to PRC2 inhibition

Archive ouverte | Romero, Pierre | CCSD

International audience. Mutations in chromatin regulators are widespread in cancer. Among them, the histone H3 lysine 27 methyltransferase Polycomb Repressive Complex 2 (PRC2) shows distinct alterations according to...

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