MicroRNA dysregulations in Merkel cell carcinoma: molecular mechanisms and clinical application

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Mazziotta, Chiara | Cervellera, Christian Felice | Lanzillotti, Carmen | Touzé, Antoine | Gaboriaud, Pauline | Tognon, Mauro | Martini, Fernanda | Rotondo, John Charles

Edité par CCSD ; Wiley-Blackwell -

International audience. Merkel cell carcinoma (MCC) is an aggressive skin malignancy with two distinct etiologies. The first, which accounts for the highest proportion, is caused by Merkel cell polyomavirus (MCPyV), a DNA tumor virus. A second, UV-induced, MCC form has also been identified. Few MCC diagnostic, prognostic and therapeutic options are available. MicroRNAs (miRNAs) are small non-coding RNA molecules, which play a key role in regulating various physiologic cellular functions including cell cycling, proliferation, differentiation, and apoptosis. Numerous miRNAs are dysregulated in cancer, by acting as either tumor suppressors or oncomiRs. The aim of this review is to collect, summarize and discuss recent findings on miRNAs whose dysregulation has been assumed to play a role in MCC. The potential clinical application of miRNAs as diagnostic and prognostic biomarkers in MCC is also described. In the future, miRNAs will potentially gain clinical significance for the improvement of MCC diagnostic, prognostic and therapeutic options. This article is protected by copyright. All rights reserved.

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