Afficher la couverture 'Interest of the Faecal and Plasma Matrix for Monitoring the Exposure of Wildlife or Domestic Animals to Anticoagulant Rodenticides | Rached, Antoine' en grand format
/5

0 avis

Interest of the Faecal and Plasma Matrix for Monitoring the Exposure of Wildlife or Domestic Animals to Anticoagulant Rodenticides

Archive ouverte

Rached, Antoine | Mahjoub, Tarek | Fafournoux, Ambre | Barbier, Brigitte | Fourel, Isabelle | Caruel, Hervé | Lefebvre, Sébastien | Lattard, Virginie

Edité par CCSD ; Elsevier -

2/1/3. International audience. Anticoagulant rodenticides (ARs), particularly second-generation compounds (SGAR), are known to be a potential threat to unintended species due to their tissue persistence. The liver is the storage tissue of ARs and is a matrix of choice in diagnosing exposure and intoxication of non-target fauna. However, it is only available on dead animals. Blood and faeces can be used on living animals. These two biological matrices were compared in terms of their relevance to exposure to ARs. In addressing this question, we compared the faecal, plasma and liver concentrations of bromadiolone, one of the SGAR frequently implicated in wildlife exposure. We studied this comparison at the individual level and at the population level, considering three influencing factors: dose, sex and time. Our findings demonstrate that faecal analyses are more valuable than plasma analyses for monitoring AR exposure of domestic and wild animals, even if faecal concentrations cannot be correlated with liver concentrations.

Suggestions

Du même auteur

Comparative pharmacokinetics of difethialone stereoisomers in male and female rats and mice: development of an intra- and inter-species model to predict the suitable formulation mix

Archive ouverte | Rached, Antoine | CCSD

International audience. The ecotoxicity of anticoagulants used for rodent pests' management is a major concern, particularly with second generation anticoagulants, which are more persistent in the body of rodents an...

Seasonal diet-based resistance to anticoagulant rodenticides in the fossorial water vole (Arvicola amphibius)

Archive ouverte | Abil Khalil, Rami | CCSD

International audience. Anticoagulant rodenticides (AR) resistance has been defined as "a major loss of efficacy due to the presence of a strain of rodent with a heritable and commensurately reduced sensitivity to t...

Management of Rodent Populations by Anticoagulant Rodenticides: Toward Third-Generation Anticoagulant Rodenticides

Archive ouverte | Damin-Pernik, Marlène | CCSD

International audience. Second-generation anticoagulant rodenticides (SGARs) have been used since the 1980s for pest management. They are highly efficient even in warfarin-resistant rodents. Nevertheless, because of...

Chargement des enrichissements...