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Altered fibrin clot structure contributes to thrombosis risk in severe COVID-19

Archive ouverte | Wygrecka, Malgorzata | CCSD

Abstract The high incidence of thrombotic events suggests a possible role of the contact system pathway in COVID-19 pathology. Here, we demonstrate altered levels of factor XII (FXII) and its activation products in two independent...

Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19

Archive ouverte | Wygrecka, Malgorzata | CCSD

International audience. Abstract The high incidence of thrombotic events suggests a possible role of the contact system pathway in COVID-19 pathology. In this study, we determined the altered levels of factor XII (F...

Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores

Archive ouverte | Schnieder, Jennifer | CCSD

International audience. In healing tissue, fibroblasts differentiate to α-smooth muscle actin (SMA)-expressing contractile-myofibroblasts, which pull the wound edges together ensuring proper tissue repair. Uncontrol...

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