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Asymmetrical Functional Deficits of ON and OFF Retinal Processing in the mdx 3Cv Mouse Model of Duchenne Muscular Dystrophy

Archive ouverte | Tsai, Tina I. | CCSD

Purpose: The dystrophin mouse mutant mdx3Cv exhibits scotopic electroretinograpic (ERG) abnormalities, which resemble clinical changes observed in Duchenne muscular dystrophy (DMD) patients. In the present study, ERGs obtained fro...

Altered visual processing in the mdx52 mouse model of Duchenne muscular dystrophy

Archive ouverte | Barboni, Mirella Telles Salgueiro | CCSD

International audience. The mdx52 mouse model of Duchenne muscular dystrophy (DMD) is lacking exon 52 of the DMD gene that is located in a hotspot mutation region causing cognitive deficits and retinal anomalies in ...

Rescue of Defective Electroretinographic Responses in Dp71-Null Mice With AAV-Mediated Reexpression of Dp71

Archive ouverte | Barboni, Mirella Telles Salgueiro | CCSD

International audience. Purpose: To study the potential effect of a gene therapy, designed to rescue the expression of dystrophin Dp71 in the retinas of Dp71-null mice, on retinal physiology.Methods: We recorded ele...

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