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PAXX and Xlf interplay revealed by impaired CNS development and immunodeficiency of double KO mice

Archive ouverte | Abramowski, Vincent | CCSD

International audience. The repair of DNA double-stranded breaks (DNAdsb) through non-homologous end joining (NHEJ) is a prerequisite for the proper development of the central nervous system and the adaptive immune ...

An XRCC4 mutant mouse, a model for human X4 syndrome, reveals interplays with Xlf, PAXX, and ATM in lymphoid development

Archive ouverte | Roch, Benoit | CCSD

International audience. We developed an Xrcc4 M61R separation of function mouse line to overcome the embryonic lethality of Xrcc4-deficient mice. XRCC4 M61R protein does not interact with Xlf, thus obliterating XRCC...

An in vivo study of the impact of deficiency in the DNA repair proteins PAXX and XLF on development and maturation of the hemolymphoid system. An in vivo study of the impact of deficiency in the DNA repair proteins PAXX and XLF on development and maturation of the hemolymphoid system: Combined PAXX and Xlf deficiency: an in vivo study

Archive ouverte | Musilli, Stefania | CCSD

International audience. The repair of DNA double strand breaks (DSBs) by the non-homologous end-joining pathway (NHEJ) is central for the proper development of the adaptive immune system. This repair pathway involve...

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