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Genetic instability from a single S phase after whole-genome duplication

Archive ouverte | Gemble, Simon | CCSD

International audience. Abstract Diploid and stable karyotypes are associated with health and fitness in animals. By contrast, whole-genome duplications—doublings of the entire complement of chromosomes—are linked t...

Genetic instability from a single S phase after whole-genome duplication

Archive ouverte | Gemble, Simon | CCSD

International audience. Abstract Diploid and stable karyotypes are associated with health and fitness in animals. By contrast, whole-genome duplications—doublings of the entire complement of chromosomes—are linked t...

Mechanisms of genetic instability in a single S-phase following whole genome doubling

Archive ouverte | Gemble, Simon | CCSD

ABSTRACT Doubling of the full chromosome content -whole genome duplications (WGDs)- is frequently found in human cancers and is responsible for the rapid evolution of genetically unstable karyotypes 1–3 . It has previously been es...

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