Afficher la couverture 'Rat lactase activity and mRNA expression in relation to the thyroid and corticoid status | Freund, Jean-Noël' en grand format
/5

0 avis

Rat lactase activity and mRNA expression in relation to the thyroid and corticoid status

Archive ouverte

Freund, Jean-Noël | Foltzer-Jourdainne, C. | Duluc, Isabelle | Galluser, M. | Gosse, F. | Raul, Francis

Edité par CCSD ; CMB Association -

The effect of glucocorticoids and thyroid hormones on lactase expression was investigated along the small intestine of rats. In sucklings thyroxine injections promoted a precocious drop of enzyme activity but not of mRNA. Hydrocortisone did neither modify lactase activity nor its mRNA expression. In adults decreasing the amount of thyroid hormones led to a slight and reversible increase of the lactase mRNA content whereas lactase activity rised more dramatically. Thus, thyroid hormones in contrast to corticoids, are involved in the posttranscriptional control of lactase during the suckling period. Yet, none of these hormones might induced the modification of the longitudinal distribution of the lactase mRNA that occurred at weaning.

Consulter en ligne

Suggestions

Du même auteur

Dietary control of the lactase mRNA distribution along the rat small intestine

Archive ouverte | Duluc, Isabelle | CCSD

At weaning, the lactase-phlorizin hydrolase (LPH) mRNA was shown to disappear specifically from the distal part of ileum while remaining abundant in the more proximal segments of the small intestine. The purpose of this study was ...

Lactase expression is controlled differently in the jejunum and ileum during development in rats

Archive ouverte | Freund, Jean-Noël | CCSD

This study shows the distribution of the messenger RNA for lactase-phlorizin hydrolase during postnatal development and along the longitudinal axis of the rat small intestine. At birth, this messenger RNA was present along the who...

Discrepancy between the intestinal lactase enzymatic activity and mRNA accumulation in sucklings and adults Effect of starvation and thyroxine treatment

Archive ouverte | Freund, Jean-Noël | CCSD

International audience

Chargement des enrichissements...