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Protein Kinase CK2 Acts as a Molecular Brake to Control NADPH Oxidase 1 Activation and Colon Inflammation

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Liu, Dan | Marie, Jean-Claude | Pelletier, Anne-Laure | Song, Zhuoyao | Ben Khemis, Marwa | Boudiaf, Kaouthar | Pintard, Coralie | Leger, Thibaut | Terrier, Samuel | Chevreux, Guillaume | El-Benna, Jamel | Dang, Pham My-Chan

Edité par CCSD ; Philadelphia, PA : American Gastroenterological Association, [2015]- -

International audience. Protein kinase CK2 is a major partner of NOXO1 in human colon epithelial cells; it directly binds and phosphorylates NOXO1 to decrease ROS generation by NOX1. In TNBSinduced colitis, the decrease in CK2 activity results in increased ROS production, thereby exacerbating inflammation.

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Protein Kinase CK2 Acts as a Molecular Brake to Control NADPH Oxidase 1 Activation and Colon Inflammation

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