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The Microenvironment Controls CDX2 Homeobox Gene Expression in Colorectal Cancer Cells

Archive ouverte | Benahmed, Fairouz | CCSD

International audience. The homeobox gene CDX2 plays a major role in development, especially in the gut, and it also acts as a tumor suppressor in the adult colon. Using orthotopic and heterotopic xenografts of huma...

The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells

Archive ouverte | Gross, Isabelle | CCSD

The gravity of colorectal cancer is mainly due to the capacity of tumor cells to migrate out of the tumor mass to invade the stroma and disseminate as metastases. The acquisition of a migratory phenotype also occurs during wound h...

Different effects of the Cdx1 and Cdx2 homeobox genes in a murine model of intestinal inflammation

Archive ouverte | Calon, A | CCSD

International audience. Aims: The CDX1 and CDX2 homeoproteins are intestine-specific transcription factors regulating homeostasis. We investigated their relevance in experimentally-induced intestinal inflammation.Me...

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