Increased risk of severe COVID-19 in hospitalized patients with SARS-CoV-2 Alpha variant infection: a multicentre matched cohort study
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Martin-Blondel, Guillaume | Lescure, François-Xavier | Assoumou, Lambert | Charpentier, Charlotte | Chapplain, Jean-Marc | Perpoint, Thomas | Grouteau, Gaspard | Cordel, Hugues | Pialoux, Gilles | Pacanowski, Jérome | Thy, Michael | Bauvois, Adeline | Laureillard, Didier | Hamrouni, Fadia | Algarte-Genin, Michèle | Poissy, Julien | Descamps, Diane | Costagliola, Dominique | Delobel, Pierre | Henaff, Jean Roch Le | Mear, Vincent | Lagarrigues, Sandra | Frelat, Alais | Nadai, Thomas De | Steinmeyer, Zara | del Bello, Arnaud | Ruiz, Stéphanie | Sarton, Benjamine | Noel-Savina, Elise | Izopet, Jacques | Peiffer-Smadja, Nathan | Gare, Mathilde | Pluart, Diane Le | Rioux, Christophe | Deconinck, Laurène | Yazdanpanah, Yazdan | Tattevin, Pierre | Bouscambert-Duchamp, Maude | Yonis, Hodane | Chabert, Paul | Mohamed-Kassim, Youssouf | Hassold, Nolan | Brichler, Segolène | Caliez, Julien | Rambaud, Thomas | Lopez-Sublet, Marilucy | Adnet, Frédéric | Palacios, Christia | Bachir, Marwa | Nadal, Marine | Turpin, Mathieu | Parrot, Antoine | Fofana, Djeneba | Lacombe, Karine | Gras, Emmanuelle | Levi, Laura | Surgers, Laure | Devred, Ines | Valin, Nadia | Chiarabini, Thibault | Meynard, Jean Luc | Duran, Clara | Gault, Elyanne | Kahn, Jean-Emmanuel | Rouveix, Elisabeth | Geri, Guillaume | Sotto, Albert | Loubet, Paul | Roger, Claire | Lambert, Marc | Assaf, Ady | Bocket, Laurence | Bani-Sadr, Firouzé | N’guyen, Yohan | Romaru, Juliette | Hentzien, Maxime | Gabas, Thomas | Chabrol, Amélie | Billiou, Cecilia | Menager, Philippe | Billy, Christophe | Laurichesse, Jean-Jacques | Simba, Fabrice Ketty N. | Paz, Pauline Caraux | Tinang, Liliane | Bounhiol, Agathe | Burnat, Catherine | Soriot-Thomas, Sandrine | Basille, Damien | Lanoix, Jean Philippe | Zerbib, Yoan | Zerbib, Yoann | Pouvaret, Anne | Lanternier, Fanny | Mascitti, Helene | Dinh, Aurélien | Davido, Benjamin | Lesprit, Philippe | Farfour, Eric | Neuville, Mathilde | Allaoua, Linda Nait | Lejaille, Michèle | Castro, Nathalie De | Molina, Jean-Michel | Ponscarme, Diane | Tateo, Mariagrazia | Liegeon, Geoffroy | Boussen, Ines | Huriez, Pauline | Cabié, André | Campana, Valentine | Calmont, Isabelle | Turmel, Jean-Marie | Karine, Guitteaud | Sandrine, Pierre-François | Marquise, Athéna | Cabras, Ornella | Lehoux, Mélanie | Chabartier, Cyrille | Dubee, Vincent | Ndiaye, Diama | Lefeuvre, Caroline | Kouatchet, Achille | Nguyen, Duc | Tumiotto, Camille | Sioniac, Pierre | Boyer, Alexandre | Faucher, Jean-François | Desvaux, Edouard | Rogez, Sylvie | Turnier, Paul Le | Raffi, François | Canet, Emmanuel | Roquilly, Antoine | Castain, Louise | Secher, Solène | Mondain, Véronique | Piroth, Lionel | Auvray, Christelle | Chavanet, Pascal | Buisson, Marielle | Mahy, Sophie | Catherine, François-Xavier | Esteve, Clementine | Duong, Michel | Charles, Carole | Gohier, Sandrine | Schaffer, Céline | Robineau, Olivier | Bortolotti, Perrine | Pradier, Maxime | Goehringer, Francois | Corbel, Alice | Kotzyba, Jeanne | Alexandre, Kévin | Beduneau, Gaetan | Alessandri-Gradt, Elodie | Martinot, Martin | Gravier, Simon | Ion, Ciprian | Lastours, Victoire De | Rahli, Roza | Garrait, Valérie | Richier, Laurent | Smati-Lafarge, Mounira | Frémont, Guillemette | Nivose, Pierre Louis | André, Marie Hélène | Gerin, Magdalena | Hamdi, Aicha | Sayre, Naomi | Cossec, Stephanie | Alviset, Sophie | Billy, Pierre Alain | Gousseff, Marie | Forestier, Emmanuel | Destrem, Anne-Laure | Rogeaux, Olivier | Bosch, Alexie | Bryant, Sabrina | Bourgeois, Gaëlle | Schaller, Ophélie dos Santos | Carret, Marie-Christine | Ettahar, Nicolas | Moudjahed, Haciba | Leone, Nathalie | Djennaoui, Mehdi | Lefebvre, Nicolas | Ursenbach, Axel | Danion, François | Ruch, Yvon | Solis, Morgane | Merdji, Hamid | Kassègne, Loïc | Pommeret, Fanny | Blameble, Emeline Colomba | Manssouria, Merad | Stoclin, Annabelle | Griscelli, Franck | Deriaz, Sophie | Oziol, Eric | Favier, Laurent | Obiols, Julien | Gicquel, Pascal | Rapp, Christophe | Louvet, Laurence | Ihout, Paul | Zabbé, Jean-Benoit | Bellec, Laurent | Chroboczek, Tomasz | Mégessier, Sandrine | Lacoste, Marie | Viala, Benjamin | Challan-Belval, Thibaut | Wackenheim, Chloé | Letertre-Gibert, Paule | Grossi, Olivier
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CCSD ; BioMed Central -
International audience.
Background: The impact of the variant of concern (VOC) Alpha on the severity of COVID-19 has been debated. We report our analysis in France.Methods: We conducted an exposed/unexposed cohort study with retrospective data collection, comparing patients infected by VOC Alpha to contemporaneous patients infected by historical lineages. Participants were matched on age (± 2.5 years), sex and region of hospitalization. The primary endpoint was the proportion of hospitalized participants with severe COVID-19, defined as a WHO-scale > 5 or by the need of a non-rebreather mask, occurring up to day 29 after admission. We used a logistic regression model stratified on each matched pair and accounting for factors known to be associated with the severity of the disease.Results: We included 650 pairs of patients hospitalized between Jan 1, 2021, and Feb 28, 2021, in 47 hospitals. Median age was 70 years and 61.3% of participants were male. The proportion of participants with comorbidities was high in both groups (85.0% vs 90%, p = 0.004). Infection by VOC Alpha was associated with a higher odds of severe COVID-19 (41.7% vs 38.5%-aOR = 1.33 95% CI [1.03-1.72]).Conclusion: Infection by the VOC Alpha was associated with a higher odds of severe COVID-19.
