A single step genetic evaluation including causal candidate SNPs for resistance to paratuberculosis in Holstein cattle

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Sanchez, Marie-Pierre | Tribout, Thierry | Fritz, Sébastien | Guatteo, Raphaël | Fourichon, Christine | Schibler, Laurent | Delafosse, Arnaud | Boichard, Didier

Edité par CCSD -

International audience. Bovine paratuberculosis, or Johne’s disease (JD), is a contagious, incurable and very difficult to control disease due to Mycobacterium avium subsp. paratuberculosis (MAP). Using a single step GBLUP, including candidate SNPs for resistance to JD, applied to a pedigree of 161,253 Holstein animals (56,766 with serological phenotypes and 12,431 with genotypes), we estimated a moderate heritability value (0.14) of this trait and detected genomic regions associated to resistance to JD on chromosomes 23, 21, 12, 3, 7, 27, 5, 10, and 20. We also estimated a slightly favorable genetic trend of resistance to JD over the last two decades and relatively reliable genomic predictions (CD = 0.55) in a validation population allowing the identification of cows at high risk of infection. Genomic predictions should therefore rapidly become an effective tool for controlling paratuberculosis in French Holstein cow farms

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