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Discovery and Refinement of a New Structural Class of Potent Peptide Deformylase Inhibitors.

Archive ouverte | Boularot, Adrien | CCSD

New classes of antibiotics are urgently needed to counter increasing levels of pathogen resistance. Peptide deformylase (PDF) was originally selected as a specific bacterial target, but a human homologue, the inhibition of which c...

Structure-activity relationship analysis of the peptide deformylase inhibitor 5-bromo-1H-indole-3-acetohydroxamic acid.

Archive ouverte | Petit, Sylvain | CCSD

International audience. The lead compound 5-bromoindolyl-3-acetohydroxamic acid (10) was recently identified as a potent inhibitor of bacterial peptide deformylases (PDFs). The synthesis and associated activities of...

New peptide deformylase inhibitors and cooperative interaction: a combination to improve antibacterial activity.

Archive ouverte | Goemaere, Emilie | CCSD

International audience. OBJECTIVES: Bacterial drug resistance is a worrying public health problem and there is an urgent need for research and development to provide new antibacterial molecules. Peptide deformylase ...

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