SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?
Archive ouverte
Sancho-Shimizu, Vanessa | Brodin, Petter | Cobat, Aurélie | Biggs, Catherine | Toubiana, Julie | Lucas, Carrie | Henrickson, Sarah | Belot, Alexandre | Haddad, Elie | Beland, Kathie | Pujol, Aurora | Schlüter, Agatha | Planas-Serra, Laura | Aguilera-Albesa, Sergio | Valencia-Ramos, Juan | Rodríguez-Palmero, Agustí | Gut, Marta | Rivière, Jacques | Colobran, Roger | Soler-Palacin, Pere | Rodriguez-Gallego, Carlos | Perez de Diego, Rebeca | Flores, Carlos | Alsina, Laia | Blazquez-Gamero, Daniel | Jordan, Iolanda | Keles, Sevgi | Emiroglu, Melike | Akcan, Ozge Metin | Alkan, Gulsum | Aytekin, Selma Erol | Gul, Yahya | Tüter Öz, Şadiye Kübra | Bozdemir, Sefika Elmas | Bayhan, Gulsum Iclal | Yüksek, Saliha Kanik | Parlakay, Aslinur Özkaya | Gülhan, Belgin | Yahşi, Aysun | Kilic, Ahmet Osman | Karbuz, Adem | Erdeniz, Emine Hafize | Özkan, Esra Akyüz | Orbak, Zerrin | Aydemir, Şehnaz | Celik, Jale Bengi | Kandemir, Bahar | Aytekin, Gökhan | Kapakli, Hasan | Yarar, Volkan | Yosunkaya, Alper | Vatansev, Hulya | Aytekin, Caner | Torun, Selda Hancerli | Nepesov, Serdar | Coskuner, Taner | Sözeri, Betül | Demirkol, Yasemin Kendir | Kasapcopur, Ozgur | Yildiz, Mehmet | Sevketoglu, Esra | Hatipoğlu, Nevin | Özçelik, Tayfun | Yesilbas, Osman | Gayretli Aydin, Zeynep Gökçe | Sediva, Anna | Klocperk, Adam | Bloomfield, Marketa | Meyts, Isabelle | Delafontaine, Selket | Haerynck, Filomeen | Hoste, Levi | Shahrooei, Mohammad | Marque, Laura | Neves, João Farela | Novelli, Giuseppe | Novelli, Antonio | Aiuti, Alessandro | Casari, Giorgio | Bousfiha, Amed Aziz | Almuhsen, Saleh Zaid | Sobh, Ali | Gagro, Alenka | Bajolle, Fanny | Bonnet, Damien | Lebon, Pierre | Lei, Weite | Lee, Danyel | Seeleuthner, Yoann | Zhang, Peng | Maglorius, Majistor | Philippot, Quentin | Pelham, Simon | Bastard, Paul | Zhang, Qian | Jouanguy, Emmanuelle | Puel, Anne | Herberg, Jethro | Kuijpers, Taco | Bellos, Evangelos | Kaforou, Myrsini | Menikou, Stephanie | Pan-Hammarström, Qiang | Hammarström, Lennart | Abolhassani, Hassan | Bryceson, Yenan | Condino-Neto, Antonio | Prando, Carolina | Bando, Silvia Yumi | Cavalcanti, Andre | Fellay, Jacques | Blanchard-Rohner, Geraldine | Mansouri, Davood | Mahmoudi, Shima | Boyarchuk, Oksana | Volokha, Alla | Bondarenko, Anastasiia | Stepanovskiy, Yuriy | Mogensen, Trine | van de Beek, Diederik | Andreakos, Evangelos | Papadaki, Maria | Abou Tayoun, Ahmad | Halwani, Rabih | Al-Mulla, Fahd | Franco, José Luis | Lau, Yu-Lung | Kwan, Mike | Imai, Kohsuke | Okada, Satoshi | Bolze, Alexandre | Butte, Manish | Hsieh, Elena | Drolet, Beth | Arkin, Lisa | Itan, Yuval | Maniatis, Tom | Arditi, Moshe | Cooper, Megan | Schmitt, Erica | Chakravorty, Samya | Anderson, Mark | Su, Helen | Notarangelo, Luigi | Tangye, Stuart | Milner, Joshua | Levin, Michael | Abel, Laurent | Bogunovic, Dusan | Casanova, Jean-Laurent | Zhang, Shen-Ying
Edité par
CCSD ; Rockefeller University Press -
International audience.
Multisystem inflammatory syndrome in children (MIS-C) emerged in April 2020 in communities with high COVID-19 rates. This new condition is heterogenous but resembles Kawasaki disease (KD), a well-known but poorly understood and clinically heterogenous pediatric inflammatory condition for which weak associations have been found with a myriad of viral illnesses. Epidemiological data clearly indicate that SARS-CoV-2 is the trigger for MIS-C, which typically occurs about 1 mo after infection. These findings support the hypothesis of viral triggers for the various forms of classic KD. We further suggest that rare inborn errors of immunity (IEIs) altering the immune response to SARS-CoV-2 may underlie the pathogenesis of MIS-C in some children. The discovery of monogenic IEIs underlying MIS-C would shed light on its pathogenesis, paving the way for a new genetic approach to classic KD, revisited as a heterogeneous collection of IEIs to viruses.
