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Rocuronium-specific antibodies drive perioperative anaphylaxis but can also function as reversal agents in preclinical models

Archive ouverte | Dejoux, Alice | CCSD

International audience. Neuromuscular blocking agents (NMBAs) relax skeletal muscles to facilitate surgeries and ease intubation but can lead to adverse reactions, including complications because of postoperative re...

An IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis

Archive ouverte | Jönsson, Friederike | CCSD

International audience. Anaphylaxis is a systemic acute hypersensitivity reaction that is considered to depend on allergen-specific immunoglobulin E (IgE) antibodies and histamine release by mast cells and basophils...

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Archive ouverte | Beutier, Héloïse | CCSD

International audience. Platelets are key regulators of vascular integrity; however, their role in anaphylaxis, a life-threatening systemic allergic reaction characterized by the loss of vascular integrity and vascu...

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