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Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway

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Prud'Homme, Mathilde | Coutrot, Maxime | Michel, Thibault | Boutin, Louis | Genest, Magali | Poirier, Françoise | Launay, Jean-Marie | Kane, Bocar | Kinugasa, Satoshi | Prakoura, Niki | Vandermeersch, Sophie | Cohen-Solal, Alain | Delcayre, Claude | Samuel, Jane-Lise | Mehta, Ravindra | Gayat, Etienne | Mebazaa, Alexandre | Chadjichristos, Christos | Legrand, Matthieu

Edité par CCSD ; Elsevier on behalf of the American College of Cardiology Foundation -

International audience. Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells. Cardiac damage could be prevented by blocking this pathway.

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