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Indoxyl-sulfate activation of the AhR- NF-κB pathway promotes interleukin-6 secretion and the subsequent osteogenic differentiation of human valvular interstitial cells from the aortic valve

Archive ouverte | Candellier, Alexandre | CCSD

International audience. Background: Calcific aortic stenosis (CAS) is more prevalent, occurs earlier, progresses faster and has worse outcomes in patients with chronic kidney disease (CKD). The uremic toxin indoxyl ...

Metformin prevents stroke damage in non-diabetic female mice with chronic kidney disease

Archive ouverte | Grissi, Maria | CCSD

International audience. Chronic kidney disease (CKD) worsens ischemic stroke severity in both patients and animals. In mice, these poorer functional outcomes are associated with decreased brain activity of AMP-activ...

Indoxyl-sulfate activation of the AhR-NFκB pathway promotes IL-6 secretion and subsequent osteogenic differentiation in human valvular interstitial cells

Archive ouverte | Issa, Nervana | CCSD

International audience. IntroductionCalcific aortic valve disease (CAVD) results from fibro-calcific degeneration of the aortic valve leaflets, causing major cardiovascular complications. In chronic kidney disease (...

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