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The evolution of the temporal program of genome replication

Archive ouverte | Agier, Nicolas | CCSD

International audience. Genome replication is highly regulated in time and space, but the rules governing the remodeling of these programs during evolution remain largely unknown. We generated genome-wide replicatio...

Reshuffling yeast chromosomes with CRISPR/ Cas9

Archive ouverte | Fleiss, Aubin | CCSD

International audience. Genome engineering is a powerful approach to study how chromosomal architecture impacts phenotypes. However, quantifying the fitness impact of translocations independently from the confoundin...

Reconstruction of ancestral chromosome architecture and gene repertoire reveals principles of genome evolution in a model yeast genus

Archive ouverte | Vakirlis, Nikolaos | CCSD

International audience. Reconstructing genome history is complex but necessary to reveal quantitative principles governing genome evolution. Such reconstruction requires recapitulating into a single evolutionary fra...

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