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Conservation of shh cis-regulatory architecture of the coelacanth is consistent with its ancestral phylogenetic position

Archive ouverte | Lang, Michael | CCSD

International audience. Abstract Background The modern coelacanth ( Latimeria ) is the extant taxon of a basal sarcopterygian lineage and sister group to tetrapods. Apart from certain apomorphic traits, its morpholo...

Cooperation of sonic hedgehog enhancers in midline expression.

Archive ouverte | Ertzer, Raymond | CCSD

International audience. In zebrafish, as in other vertebrates, the secreted signalling molecule Sonic hedgehog (Shh) is expressed in organiser regions such as the embryonic midline and the zona limitans intrathalami...

The words of the regulatory code are arranged in a variable manner in highly conserved enhancers.

Archive ouverte | Rastegar, Sepand | CCSD

International audience. The cis-regulatory regions of many developmental regulators and transcription factors are believed to be highly conserved in the genomes of vertebrate species, suggesting specific regulatory ...

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