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A synthetic synaptic organizer protein restores glutamatergic neuronal circuits

Archive ouverte | Suzuki, Kunimichi | CCSD

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Multiomic ALS signatures highlight sex differences and molecular subclusters and identify the MAPK pathway as therapeutic target

Archive ouverte | Gomes, Lucas Caldi | CCSD

Abstract Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease and lacks effective disease-modifying treatments. Here, we performed a multiomic analysis of the prefrontal cortex of 51 patients with sporadic A...

Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target

Archive ouverte | Caldi Gomes, Lucas | CCSD

International audience. Amyotrophic lateral sclerosis (ALS) is a debilitating motor neuron disease and lacks effective disease-modifying treatments. This study utilizes a comprehensive multiomic approach to investig...

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