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Targeting Glutamine Metabolism and PD-L1: A Novel Anti-tumor Pas de Deux

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Matias, Maria | Dardalhon, Valérie | Taylor, Naomi

Edité par CCSD ; Cell Press -

Refers toJun-Kyu Byun, Mihyang Park, Seunghyeong Lee, Jae Won Yun, Jaebon Lee, Jae Sun Kim, Sung Jin Cho, Hui-Jeon Jeon, In-Kyu Lee, Yeon-Kyung Choi, Keun-Gyu ParkInhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor ImmunityMolecular Cell, Volume 80, Issue 4, 19 November 2020, Pages 592-606.e8. International audience. In this issue of Molecular Cell, Byun et al. (2020) find that the dual targeting of glutamine metabolism and the PD-L1 checkpoint inhibitor augments anti-tumor immunity. Mechanistically, decreased glutamine availability attenuated S-glutathionylation of SERCA, resulting in an increase in cytosolic calcium, enhanced NF-κB activity, and upregulation of programmed death-ligand 1.

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