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Targeting DNA repair by coDbait enhances melanoma targeted radionuclide therapy

Archive ouverte | Viallard, Claire | CCSD

International audience. Radiolabelled melanin ligands offer an interesting strategy for the treatment of disseminated pigmented melanoma. One of these molecules, ICF01012 labelled with iodine 131, induced a signific...

Theranostic Approach for Metastatic Pigmented Melanoma Using ICF15002, a Multimodal Radiotracer for Both PET Imaging and Targeted Radionuclide Therapy

Archive ouverte | Rbah-Vidal, Latifa | CCSD

International audience. PURPOSE: This work reports, in melanoma models, the theranostic potential of ICF15002 as a single fluorinated and iodinated melanin-targeting compound. METHODS: Studies were conducted in the ...

Radiation dosimetry of [ 131 I]ICF01012 in rabbits: Application to targeted radionuclide therapy for human melanoma treatment

Archive ouverte | Jouberton, Elodie | CCSD

International audience. Dosimetry for melanoma-targeted radionuclide therapy (TRT) with [131 I]ICF01012, a melanin ligand, has been previously evaluated in mice bearing melanomas. In this study, activity distributio...

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