Afficher la couverture 'Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia | Diabasana, Zania' en grand format
/5

0 avis

Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia

Archive ouverte

Diabasana, Zania | Perotin, Jeanne-Marie | Belgacemi, Randa | Ancel, Julien | Mulette, Pauline | Launois, Claire | Delepine, Gonzague | Dubernard, Xavier | Mérol, Jean-Claude | Ruaux, Christophe | Gosset, Philippe | Maskos, Uwe | Polette, Myriam | Deslée, Gaëtan | Dormoy, Valérian

Edité par CCSD ; MDPI -

International audience. The gene cluster region, CHRNA3/CHRNA5/CHRNB4, encoding for nicotinic acetylcholine receptor (nAChR) subunits, contains several genetic variants linked to nicotine addiction and brain disorders. The CHRNA5 single-nucleotide polymorphism (SNP) rs16969968 is strongly associated with nicotine dependence and lung diseases. Using immunostaining studies on tissue sections and air-liquid interface airway epithelial cell cultures, in situ hybridisation, transcriptomic and cytokines detection, we analysed rs16969968 contribution to respiratory airway epithelial remodelling and modulation of inflammation. We provide cellular and molecular analyses which support the genetic association of this polymorphism with impaired ciliogenesis and the altered production of inflammatory mediators. This suggests its role in lung disease development.

Suggestions

Du même auteur

Glypican-3 is a key tuner of the Hedgehog pathway in COPD

Archive ouverte | Petit, Laure, M G | CCSD

International audience. Hedgehog (HH) pathway is involved in pulmonary development and lung homeostasis. It orchestrates airway epithelial cell (AEC) differentiation and contributes to respiratory pathogenesis.The c...

Impaired Ciliary Beat Frequency and Ciliogenesis Alteration during Airway Epithelial Cell Differentiation in COPD

Archive ouverte | Ancel, Julien | CCSD

International audience. Chronic obstructive pulmonary disease (COPD) is a frequent respiratory disease. However, its pathophysiology remains partially elucidated. Epithelial remodeling including alteration of the ci...

The Nicotinic Receptor Polymorphism rs16969968 Is Associated with Airway Remodeling and Inflammatory Dysregulation in COPD Patients

Archive ouverte | Saber Cherif, Lynda | CCSD

International audience. Genome-wide association studies unveiled the associations between the single nucleotide polymorphism rs16969968 of CHRNA5, encoding the nicotinic acetylcholine receptor alpha5 subunit (α5SNP)...

Chargement des enrichissements...