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Prevalence of antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis and spatial association with quarries in a French Northeast region

Archive ouverte | Giorgiutti, Stéphane | CCSD

Objective: Silica is one of the strongest environmental substances linked with autoimmunity. The aim of this study was to assess the prevalence of granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and renal li...

B cells in primary antiphospholipid syndrome: Review and remaining challenges

Archive ouverte | Dieudonné, Yannick | CCSD

It is now widely accepted that antiphospholipid antibodies (aPL) have direct pathogenic effects and that B cells, notably through aPL production, play a key role in the development of antiphospholipid syndrome (APS). Recent findin...

Transitional B cells in quiescent SLE: An early checkpoint imprinted by IFN

Archive ouverte | Dieudonné, Yannick | CCSD

Systemic lupus (SLE) is characterized by a break of B cell tolerance that plays a central role in disease pathophysiology. An early checkpoint defect occurs at the transitional stage leading to the survival of autoreactive B cells...

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