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Clinical characteristics and outcome of hospitalized patients with SARS-CoV-2 infection at Toulouse University hospital (France). Results from the Covid-clinic-Toul cohort. Caractéristiques cliniques et évolution des patients hospitalisés pour une infection au SARS-CoV-2 au CHU de Toulouse. Résultats de la cohorte Covid-clinic-Toul
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International audience. Background. – Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread world-wide from epicenter of Wuhan, China since December 2019. The aim of our study was to describe theclinical characteristics and outcome of hospitalized patients with SARS-CoV-2 pneumonia at the Toulouseuniversity hospital, France.Patients and methods. – We selected the patients included from March 7, 2020 to April 20, 2020 in theretrolective Covid-clinic-Toul cohort that follows all hospitalized patients with SARS-CoV-2 infectionat the Toulouse Hospital. Cases were confirmed by real-time reverse transcriptase polymerase chainreaction. We report demographics, clinical, biological and radiological features, as well as unfavorableoutcome at Day 14 after admission (admission in an intensive care unit, mechanical ventilation, death).Results. – Among 263 hospitalized patients, the median age was 65 years and 155 (58.9%) were males.Two hundred and twenty-seven patients (86.3%) had at least one comorbidity. The median time fromfirst symptom to hospital admission was 7.0 days (interquartile range: 4–10). On day 14 after admission,111 patients (42.2%) had been transferred to intensive care unit (ICU), including 50 (19.0%) on Day 1; 61(23.1%) needed mechanical ventilation and 19 patients (7.2%) had died. Patients admitted to ICU at Day 1of admission (n = 50) were more frequently men (66.0% vs 57.3%), smokers (25.0% vs 7.1%), with obesity(42.0% vs 24.7%) and had a higher mean level of C-reactive protein (median: 110.9 mg/L vs 46.2 mg/L).Conclusion. – This cohort provides epidemiological data on SARS-CoV-2 in hospitalized patients in aUniversity hospital in the South of France
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