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Skin Autofluorescence of Pregnant Women With Diabetes Predicts the Macrosomia of Their Children
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Edité par CCSD ; American Diabetes Association -
International audience. Advanced Glycation End-products (AGEs) accumulated during long-term hyperglycemia are involved in diabetes complications and can be estimated by skin Autofluorescence (sAF). During pregnancy, hyperglycemia exposes to the risk of having a macrosomic newborn. The aim of this study was to determine whether sAF of women with diabetes during a singleton pregnancy could predict macrosomia in their newborns. Using an AGE-Reader, we measured the sAF at the first visit of 343 women who were referred to our Diabetology department during years 2011-2015. Thirty-nine women had pregestational diabetes, 95 early Gestational Diabetes Mellitus (GDM) and 209 late GDM. Macrosomia was defined as birth weight >/=4000g and/or Large for Gestational Age (LGA) >/=90(th) centile. Forty-six newborns were macrosomic. Their mothers had +11% higher sAF compared to other mothers: 2.03+/-0.30 Arbitrary Unit (AU) vs 1.80+/-0.34 (p<0.0001). Using multivariate logistic regression, the relation between sAF and macrosomia was significant (OR: 4.13 for 1AU increase of sAF; 95%CI: 1.46-11.71) after adjusting for several potential confounders. This relation remained significant after further adjustment for HbA1c (among 263 women with available HbA1c), and for women with GDM only. sAF of pregnant women with diabetes, a marker of long-term hyperglycemic exposure, predicts macrosomia in their newborns.
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