Afficher la couverture 'Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19 | Guervilly, Christophe' en grand format
/5

0 avis

Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19

Archive ouverte

Guervilly, Christophe | Burtey, Stéphane | Sabatier, Florence | Cauchois, Raphaël | Lano, Guillaume | Abdili, Evelyne | Daviet, Florence | Arnaud, Laurent | Brunet, Philippe | Hraiech, Sami | Jourde-Chiche, Noémie | Koubi, Marie | Lacroix, Romaric | Pietri, Léa | Berda, Yaël | Robert, Thomas | Degioanni, Clara | Velier, Mélanie | Papazian, Laurent | Kaplanski, Gilles | Dignat-George, Francoise

Edité par CCSD ; Oxford University Press -

International audience. Beside the commonly described pulmonary expression of the coronavirus disease 2019 (COVID-19), major vascular events have been reported. The objective of this study was to investigate whether increased levels of circulating endothelial cells (CECs) might be associated with severe forms of COVID-19. Ninety-nine patients with COVID-19 were enrolled in this retrospective study. Patients in the intensive care units (ICU) had significantly higher CEC counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines. Together, these data provide in vivo evidence that endothelial injury is a key feature of COVID-19.

Suggestions

Du même auteur

Dissemination of extreme levels of extracellular vesicles: tissue factor activity in patients with severe COVID-19

Archive ouverte | Guervilly, Christophe | CCSD

International audience. Abstract Coronavirus disease 2019 (COVID-19) has become one of the biggest public health challenges of this century. Severe forms of the disease are associated with a thrombo-inflammatory sta...

Caspase-1 activation, IL-1/IL-6 signature and IFNγ-induced chemokines in lungs of COVID-19 patients

Archive ouverte | Cambon, Audrey | CCSD

International audience. Rationale COVID-19-associated acute-respiratory distress syndrome (C-ARDS) results from a direct viral injury associated with host excessive innate immune response mainly affecting the lungs....

Rheopheresis Performed in Hemodialysis Patients Targets Endothelium and Has an Acute Anti-Inflammatory Effect

Archive ouverte | Solignac, Justine | CCSD

International audience. Rheopheresis is a double-filtration plasmapheresis that removes a defined spectrum of high-molecular-weight proteins to lower plasma viscosity and improves microcirculation disorders. This te...

Chargement des enrichissements...