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Hydroxychloroquine in Coronavirus Disease 2019 Patients: What Still Needs to Be Known About the Kinetics

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Martin-Blondel, Guillaume | Ruiz, Stéphanie | Murris, Marlene | Faguer, Stanilas | Duhalde, Véronigue | Eyvrard, Frédéric | Izopet, Jacques | Mansuy, Jean-Michel | Rolland, Yves | Delavigne, Karen | Guimbaud, Rosine | Pugnet, Grégory | Conil, Jean-Marie | Georges, Bernard | Delobel, Pierre | Minville, Vincent | Silva Sifontes, Stein | Concordet, Didier | Gandia, Peggy

Edité par CCSD ; Oxford University Press (OUP) -

International audience. Different dosage regimens of hydroxychloroquine are used to manage coronavirus disease 2019 (COVID-19) patients, without information on the pharmacokinetics in this population. Blood samples (n = 101) were collected from 57 COVID-19 patients for 7 days, and concentrations were compared with simulated kinetic profiles. Hydroxychloroquine exposure is low and cannot be predicted by other populations.

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