The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis

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Enaud, R. | Vandenborght, L. E. | Coron, N. | Bazin, T. | Prevel, R. | Schaeverbeke, T. | Berger, P. | Fayon, M. | Lamireau, Thierry | Delhaes, L.

Edité par CCSD ; MDPI -

International audience. In recent years, the gut microbiota has been considered as a full-fledged actor of the gut-brain axis, making it possible to take a new step in understanding the pathophysiology of both neurological and psychiatric diseases. However, most of the studies have been devoted to gut bacterial microbiota, forgetting the non-negligible fungal flora. In this review, we expose how the role of the fungal component in the microbiota-gut-brain axis is legitimate, through its interactions with both the host, especially with the immune system, and the gut bacteria. We also discuss published data that already attest to a role of the mycobiome in the microbiota-gut-brain axis, and the impact of fungi on clinical and therapeutic research.

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