Utilization of Galectins by Pathogens for Infection

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Ayona, Diyoly | Fournier, Pierre-Edouard | Henrissat, Bernard | Desnues, Benoit

Edité par CCSD ; Frontiers -

International audience. Galectins are glycan-binding proteins which are expressed by many different cell types and secreted extracellularly. These molecules are well-known regulators of immune responses and involved in a broad range of cellular and pathophysiological functions. During infections, host galectins can either avoid or facilitate infections by interacting with host cells-and/or pathogen-derived glycoconjugates and less commonly, with proteins. Some pathogens also express self-produced galectins to interfere with host immune responses. This review summarizes pathogens which take advantage of host-or pathogen-produced galectins to establish the infection.

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