Afficher la couverture 'Intergenerationally Maintained Histone H4 Lysine 16 Acetylation Is Instructive for Future Gene Activation | Samata, Maria' en grand format
/5

0 avis

Intergenerationally Maintained Histone H4 Lysine 16 Acetylation Is Instructive for Future Gene Activation

Archive ouverte

Samata, Maria | Alexiadis, Anastasios | Richard, Gautier | Georgiev, Plamen | Nuebler, Johannes | Kulkarni, Tanvi | Renschler, Gina | Basilicata, M. Felicia | Zenk, Fides Lea | Shvedunova, Maria | Semplicio, Giuseppe | Mirny, Leonid | Iovino, Nicola | Akhtar, Asifa

Edité par CCSD ; Elsevier -

International audience. Before zygotic genome activation (ZGA), the quiescent genome undergoes reprogramming to transition into the transcriptionally active state. However, the mechanisms underlying euchromatin establishment during early embryogenesis remain poorly understood. Here, we show that histone H4 lysine 16 acetylation (H4K16ac) is maintained from oocytes to fertilized embryos in Drosophila and mammals. H4K16ac forms large domains that control nucleosome accessibility of promoters prior to ZGA in flies. Maternal depletion of MOF acetyltransferase leading to H4K16ac loss causes aberrant RNA Pol II recruitment, compromises the 3D organization of the active genomic compartments during ZGA, and causes downregulation of post-zygotically expressed genes. Germline depletion of histone deacetylases revealed that other acetyl marks cannot compensate for H4K16ac loss in the oocyte. Moreover, zygotic re-expression of MOF was neither able to restore embryonic viability nor onset of X chromosome dosage compensation. Thus, maternal H4K16ac provides an instructive function to the offspring, priming future gene activation.

Consulter en ligne

Suggestions

Du même auteur

Hi-C guided assemblies reveal conserved regulatory topologies on X and autosomes despite extensive genome shuffling.

Archive ouverte | Renschler, Gina | CCSD

International audience. Genome rearrangements that occur during evolution impose major challenges on regulatory mechanisms that rely on three-dimensional genome architecture. Here, we developed a scaffolding algorit...

De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation

Archive ouverte | Basilicata, M Felicia | CCSD

International audience. The etiological spectrum of ultra-rare developmental disorders remains to be fully defined. Chromatin regulatory mechanisms maintain cellular identity and function, where misregulation may le...

MSL2 variants lead to a neurodevelopmental syndrome with lack of coordination, epilepsy, specific dysmorphisms, and a distinct episignature

Archive ouverte | Karayol, Remzi | CCSD

International audience. Epigenetic dysregulation has emerged as an important etiological mechanism of neurodevelopmental disorders (NDDs). Pathogenic variation in epigenetic regulators can impair deposition of histo...

Chargement des enrichissements...