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The rise and fall of the ancient northern pike master sex-determining gene

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Pan, Qiaowei | Feron, Romain | Jouanno, Elodie | Darras, Hugo | Herpin, Amaury | Koop, Ben | Rondeau, Eric | Goetz, Frederick, W | Larson, Wesley, A | Bernatchez, Louis | Tringali, Mike | Curran, Stephen, S | Saillant, Eric | Denys, Gael Pj | von Hippel, Frank, A | Chen, Songlin | López, J Andrés | Verreycken, Hugo | Ocalewicz, Konrad | Guyomard, René | Eche, Camille | Lluch, Jerome | Roques, Celine | Hu, Hongxia | Tabor, Roger | Dehaan, Patrick | Nichols, Krista | Journot, Laurent | Parrinello, Hugues | Klopp, Christophe | Interesova, Elena, A | Trifonov, Vladimir | Schartl, Manfred | Postlethwait, John | Guiguen, Yann

Edité par CCSD ; eLife Sciences Publication -

International audience. The understanding of the evolution of variable sex determination mechanisms across taxa requires comparative studies among closely related species. Following the fate of a known master sex-determining gene, we traced the evolution of sex determination in an entire teleost order (Esociformes). We discovered that the northern pike (Esox lucius) master sex-determining gene originated from a 65 to 90 million-year-old gene duplication event and that it remained sex linked on undifferentiated sex chromosomes for at least 56 million years in multiple species. We identified several independent species- or population-specific sex determination transitions, including a recent loss of a Y chromosome. These findings highlight the diversity of evolutionary fates of master sex-determining genes and the importance of population demographic history in sex determination studies. We hypothesize that occasional sex reversals and genetic bottlenecks provide a non-adaptive explanation for sex determination transitions.

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