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Inactivation of Exosc10 in the oocyte impairs oocyte development and maturation, leading to a depletion of the ovarian reserve in mice

Archive ouverte | Demini, Leïla | CCSD

International audience. EXOSC10 is a catalytic subunit of the nuclear RNA exosome, and possesses a 3'-5' exoribonuclease activity. The enzyme processes and degrades different classes of RNAs. To delineate the role o...

EXOSC10/Rrp6 is post-translationally regulated in male germ cells and controls the onset of spermatogenesis

Archive ouverte | Jamin, Soazik P. | CCSD

International audience. EXOSC10 is a catalytic subunit of the exosome that processes biologically active transcripts, degrades aberrant mRNAs and targets certain long non-coding RNAs (lncRNAs). The yeast orthologue ...

EXOSC10/Rrp6 is essential for the eight-cell embryo/morula transition

Archive ouverte | Petit, Fabrice G. | CCSD

International audience. The conserved 30-50 exoribonuclease EXOSC10/Rrp6 is required for gametogenesis, brain development, erythropoiesis and blood cell enhancer function. The human ortholog is essential for mitosis...

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