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NGS-based stratification refines the risk stratification in T-ALL and identifies a very-high-risk subgroup of patients

Archive ouverte | Simonin, Mathieu | CCSD

International audience. We previously reported a better outcome in adult and pediatric T-cell acute lymphoblastic leukemia (T-ALL) harboring NOTCH1 and/or FBXW7 mutations without alterations of K-N-RAS and PTEN gene...

Clinico-biological features of T-cell acute lymphoblastic leukemia with fusion proteins

Archive ouverte | Steimlé, Thomas | CCSD

International audience. T-cell acute lymphoblastic leukemias (T-ALL) represent 15% of pediatric and 25% of adult ALL. Since they have a particularly poor outcome in relapsed/refractory cases, identifying prognosis f...

Oncogenetic landscape and clinical impact of IDH1 and IDH2 mutations in T-ALL

Archive ouverte | Simonin, Mathieu | CCSD

International audience. IDH1 and IDH2 mutations (IDH1/2 Mut) are recognized as recurrent genetic alterations in acute myeloid leukemia (AML) and associated with both clinical impact and therapeutic opportunity due t...

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