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Induction of the ISR by AB5 subtilase cytotoxin drives type-I IFN expression in pDCs via STING activation

Archive ouverte | Barros, Daniela | CCSD

International audience. SUMMARY We demonstrate that exposure to the AB5 subtilase cytotoxin (SubAB) induces the unfolded protein response (UPR) in human peripheral blood mononuclear cells, concomitant with a pro-inf...

VPS34-IN1 inhibits cap-mediated translation and synergizes with STING to drive type-I IFN expression in human plasmacytoid DCs

Archive ouverte | Antas, Paulo | CCSD

International audience. Abstract Inhibition of the phosphatidylinositol kinase vacuolar protein sorting 34 (VPS34) with the pharmacological compound VPS34-IN1 has a range of effects on the dynamics of endosomes. Whi...

Protein synthesis inhibition and GADD34 control IFN‐β heterogeneous expression in response to dsRNA

Archive ouverte | Dalet, Alexandre | CCSD

International audience. In innate immune responses, induction of type-I interferons (IFNs) prevents virus spreading while viral replication is delayed by protein synthesis inhibition. We asked how cells perform thes...

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