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Themis2 lowers the threshold for B cell activation during positive selection

Archive ouverte | Cheng, Daian | CCSD

International audience

CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens

Archive ouverte | Blaize, Gaëtan | CCSD

International audience. CD5 is characterized as an inhibitory coreceptor with an important regulatory role during T cell development. The molecular mechanism by which CD5 operates has been puzzling and its function ...

Grb2-Mediated Recruitment of USP9X to LAT Enhances Themis Stability following Thymic Selection

Archive ouverte | Garreau, Anne | CCSD

International audience. Abstract Themis is a new component of the TCR signaling machinery that plays a critical role during T cell development. The positive selection of immature CD4+CD8+ double-positive thymocytes ...

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