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A snake toxin as a theranostic agent for the type 2 vasopressin receptor

Archive ouverte | Droctové, Laura | CCSD

International audience. Rationale: MQ1, a snake toxin which targets with high nanomolar affinity and absolute selectivity for the type 2 vasopressin receptor (V2R), is a drug candidate for renal diseases and a molec...

MQ232, A Snake Toxin Derivative for Treatment of Hyponatremia and Polycystic Kidney Diseases

Archive ouverte | Stanajic-Petrovic, Goran | CCSD

International audience. Background: Vaptans were developed at the end of the previous century as V2R antagonists. Tolvaptan is the most prescribed vaptan for hyponatremia and the autosomal polycystic kidney disease ...

A new Kunitz‐type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor

Archive ouverte | Droctové, Laura | CCSD

International audience. Background and Purpose: Venomous animals express numerous Kunitz-type peptides. The mambaquaretin-1 (MQ1) peptide identified from the Dendroaspis angusticeps venom is the most selective antag...

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