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An NF90/NF110-mediated feedback amplification loop regulates dicer expression and controls ovarian carcinoma progression

Archive ouverte | Barbier, Jérome | CCSD

International audience. Reduced expression of DICER, a key enzyme in the miRNA pathway, is frequently associated with aggressive, invasive disease, and poor survival in various malignancies. Regulation of DICER expr...

Chromatin-associated MRN complex protects highly transcribing genes from genomic instability

Archive ouverte | Salifou, Kader | CCSD

The MRN-MDC1 complex plays a central role in the DNA damage response (DDR) and repair. Using Proteomics of Isolated Chromatin Fragments (PICh), we identified DDR factors, such as MDC1, among those that become highly associated wit...

Chromatin-associated MRN complex protects highly transcribing genes from genomic instability

Archive ouverte | Salifou, Kader | CCSD

International audience. MRN-MDC1 plays a central role in the DNA damage response (DDR) and repair. Using proteomics of isolated chromatin fragments, we identified DDR factors, such as MDC1, among those highly associ...

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