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Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies

Archive ouverte | Saliba, J. | CCSD

International audience. No major predisposition gene for familial myeloproliferative neoplasms (MPN) has been identified. Here we demonstrate that the autosomal dominant transmission of a 700-kb duplication in four ...

Heterozygous and homozygous JAK2(V617F) states modeled by induced pluripotent stem cells from myeloproliferative neoplasm patients

Archive ouverte | Saliba, Joseph | CCSD

International audience. JAK2(V617F) is the predominant mutation in myeloproliferative neoplasms (MPN). Modeling MPN in a human context might be helpful for the screening of molecules targeting JAK2 and its intracell...

Caspase-activated rock-1 allows erythroblast terminal maturation independently of cytokine-induced RHO signaling.

Archive ouverte | Gabet, A.S. | CCSD

International audience. Stem cell factor (SCF) and erythropoietin are strictly required for preventing apoptosis and stimulating proliferation, allowing the differentiation of erythroid precursors from colony-formin...

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