Upper and Lower Motor Neuron Degenerations Are Somatotopically Related and Temporally Ordered in the Sod1 Mouse Model of Amyotrophic Lateral Sclerosis

Archive ouverte | Marques, Christine | CCSD

International audience. Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disease arising from the combined degeneration of upper motor neurons (UMN) in the motor cortex, and lower mot...

Evidence that corticofugal propagation of ALS pathology is not mediated by prion-like mechanism

Archive ouverte | Scekic-Zahirovic, Jelena | CCSD

Cortical Circuit Dysfunction as a Potential Driver of Amyotrophic Lateral Sclerosis

Archive ouverte | Brunet, Aurore | CCSD

International audience. Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that affects selected cortical and spinal neuronal populations, leading to progressive paralysis and death. A gr...